Neoplastic Gastrointestinal Pathology by Laura Lamps MD, Andrew Bellizzi MD, Wendy L. Frankel MD,

By Laura Lamps MD, Andrew Bellizzi MD, Wendy L. Frankel MD, Scott R. Owens MD, Rhonda Yantiss MD


nearly 20 million gastrointestinal tract biopsies are played every year within the usa. whereas lots of those are undemanding, a few are histologically sophisticated or contain a fancy differential analysis. This concise visible advisor to the entire diversity of neoplastic gastrointestinal specimens presents the practising pathologist or trainee with a transparent research and analysis of either universal and almost certainly deceptive variations of ailment. The authors conceal the complete tubular GI tract with over six hundred high quality photographs and a concise description of the most important good points of every entity: definitions and terminology, gross and morphologic positive aspects, differential diagnoses, necessary ancillary assessments, staging and grading parameters, and specific scientific concerns. photos depict differential analysis gains, usually visible versions which may almost certainly result in misclassification or misdiagnosis, and correlated molecular and immunologic recommendations.


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Neoplastic Gastrointestinal Pathology

" nearly 20 million gastrointestinal tract biopsies are played every year within the usa. whereas a lot of those are simple, a few are histologically refined or contain a posh differential prognosis. This concise visible consultant to the complete diversity of neoplastic gastrointestinal specimens offers the working towards pathologist or trainee with a transparent research and analysis of either universal and in all probability deceptive variations of affliction.

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6 summarizes immunohistochemical markers that are commonly used in the diagnosis of epithelial neoplasms, as well as their most frequent uses. The utility of immunohistochemistry in the diagnosis of neoplasms of the GI tract will be discussed in more detail in Chapter 13. GENERAL APPROACH TO THE DIAGNOSIS OF EPITHELIAL NEOPLASMS The general approach to the diagnosis of any epithelial neoplasm in the GI tract begins with a review of the patient’s history, including age, gender, and previous malignancies or lesions such as adenomas or hamartomatous polyps.

Miettinen M, Lasota J. Histopathology of gastrointestinal stromal tumor. J Surg Oncol. 2011;104:865–873. Ordóñez NG. Broad-spectrum immunohistochemical epithelial markers: a review. Human Pathology. 2013;44:1195–1215. 3 Approach to Neuroendocrine Neoplasms A N DR E W M . BE LL I Z Z I INTRODUCTION HISTORICAL PERSPECTIVE The term “neuroendocrine epithelial neoplasms” (NENs) encompasses both well-differentiated tumors, historically referred to as carcinoid tumors, and poorly differentiated ones (small cell and large cell neuroendocrine carcinomas).

This example of endometriosis near the mucosal surface shows mucin-depleted cells with enlarged nuclei that mimic dysplastic crypts (A–B), but there is surrounding endometrial-type stroma. Endometrial stroma is composed of densely packed small cells, and should be distinguished from true desmoplasia (C). Endometrial stroma may be inconspicuous in some cases, but hemosiderin deposition can also be a clue to the diagnosis (D). Prolapse Change or Misplaced Epithelium The solitary rectal ulcer syndrome, colitis cystica profunda, and other forms of mucosal prolapse are a related spectrum of disorders in which benign, often dilated glands may herniate into the submucosa, often due to excessive straining during defecation.

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