By Sudha R. Kini MD
Cytopathology of Neuroendocrine Neoplasia: Color Atlas and Text
The neuroendocrine procedure is attention-grabbing. it's an interesting, complicated process. for hundreds of years, it has sustained the curiosity of scientists, who've supplied the neighborhood with a wealth of data on neuroendocrine tumors types—history, genetics, medical presentation, surgical pathology, differential diagnoses…on every little thing except cytopathology…until now.
This distinctive colour atlas fills a long-standing void in neuroendocrine assets. This atlas offers transparent, descriptive details at the cytopathology of neuroendocrine tumor types and differential diagnoses in a single state of the art, accomplished source. This distinct atlas is devoted solely to delivering professional, illustrated insurance of the cytopathology of neuroendocrine tumors.
Inside, the content material addresses the huge distribution of the neuroendocrine cells within the physique and the ever present nature in their neoplasms. Readers also will discover certain descriptions of the morphologic spectrum of the neoplasms (including diversified terminologies), in addition to their immunocytohistochemical houses, linked ultrastructural findings, secretory items, and their organization with many hereditary syndromes.
Put the ability of this atlas to paintings for you!
• unique insurance of cytomorphology of neuroendocrine neoplasia presents info no longer present in textbooks
• present tumor classifications for every physique system are integrated as an appendix on the finish of every chapter.
• Over one thousand full-color photos detail a number tumor websites and kinds, supporting in refining the differential diagnosis.
• convenient glossary is helping make clear ameliorations in terminology.
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Additional info for Cytopathology of Neuroendocrine Neoplasia: Color Atlas and Text
Color Atlas of Pulmonary Cytopathology. ; 2002. a neuroendocrine tumor can be easily made, but the diagnostic specificity is low. 10). METASTATIC ATYPICAL CARCINOID TUMORS TO OTHER BODY SITES Atypical carcinoid tumors metastasize more frequently than typical carcinoid tumors do. The common sites are hilar/mediastinal lymph nodes, liver, bones, serous membranes skin, and subcutaneous tissues. 47 LARGE CELL NEUROENDOCRINE CARCINOMA (LCNEC), (NEC, GRADE III, POORLY DIFFERENTIATED NEC, HIGHGRADE NEC) LCNECs have been fairly recently recognized as a subtype of pulmonary neuroendocrine tumors, characterized by their distinctive morphology such as neuroendocrine growth patterns, large cells with coarse nuclear chromatin, prominent nucleoli, variable amounts of cytoplasm, high mitotic rate, infarct-like necrosis, and neuroendocrine differentiation both immunohistochemically and ultrastructurally.
The carcinoid tumors are often submucosal in location and do not yield to brushings. In bronchial washings, the carcinoid tumor cells tend to shrink and are not easily recognized (Fig. 8). The bronchial epithelium overlying a submucosal lesion may undergo squamous metaplasia. With varying degrees of cellular and nuclear atypia, the brushings of this metaplastic squamous epithelium may be interpreted as squamous carcinoma, resulting in a false-positive diagnosis (Fig. 21A–C). 3). The benign entities, such as reserve cell hyperplasia, bronchial epithelial cell (columnar cell) hyperplasia, lymphocytes, and alveolar lining cells (in washings and lavage specimens), may mimic the cells of carcinoid tumor (see Figs.
All Rights Reserved. Chapter 3: Pulmonary Neuroendocrine Tumors 45 A B Fig. 26: Metastatic Pulmonary Carcinoid Tumor in Liver. A: FNA of a liver mass in a patient with a history of pulmonary carcinoid tumor (same case as Fig. 4). B: Another example of a metastatic pulmonary carcinoid to the liver. FNA of one of the multiple liver nodules with typical cytomorphology of carcinoid tumor. Fig. 27: Metastatic Pulmonary Carcinoid Tumor in Serous Effusion Fluid. This syncytial tissue fragment of neoplastic cells shows morphology that is suggestive of an adenocarcinoma.