Cancer Chemotherapy by Alan C. Sartorelli (Eds.)

By Alan C. Sartorelli (Eds.)

content material: improvement of [alpha]-(N)-heterocyclic carboxaldehyde thiosemicarbazones with scientific strength as antineoplastic brokers / Alan C. Sartorelli and Krishna C. Agrawal --
Adriamycin / David W. Henry --
Biochemical pharmacology of the anthracycline antibiotics / Nicholas R. Bachur --
power bioreductive alkylating brokers / Ai Jeng Lin, Lucille A. Cosby, and Alan C. Sartorelli --
A evaluate of experiences at the mechanism of motion of nitrosoureas / Glynn P. Wheeler.

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HENRY Adriamycin 23 The c e l l c y c l e phase s p e c i f i c i t i e s of daunomycin and a d r i a mycin have been i n v e s t i g a t e d by s e v e r a l groups but general c o n c l u sions cannot yet be drawn. Tobey (78) and Kim et a l . (79,80) report both a n t i b i o t i c s to be S-phase s p e c i f i c i n Chinese hamster and HeLa c e l l s , r e s p e c t i v e l y . Bhuyan and F r a s e r concluded s i m i l a r l y f o r adriamycin i n Chinese hamster f i b r o b l a s t s (81).

42% and l a c k of long-term s u r v i v o r s given by adriamycin. In c o n t r a s t AD32 gave f i v e out of seven 60-day s u r v i v o r s , an imp r e s s i v e r e s u l t as long-term s u r v i v o r s w i t h any a n t h r a c y c l i n e a r e not common i n the L1210 system. As expected with an N-acylated d e r i v a t i v e optimum dose l e v e l s f o r AD32 a r e at l e a s t t e n - f o l d g r e a t e r than f o r adriamycin. Before l e a v i n g t h i s group of d e r i v a t i v e s i t should be noted that t h e i r b i o l o g i c a l a c t i v i t i e s a r e g e n e r a l l y i n q u a l i t a t i v e agreement with the r e c e p t o r s i t e hypothesis d i s c u s s e d above.

In c o n t r a s t AD32 gave f i v e out of seven 60-day s u r v i v o r s , an imp r e s s i v e r e s u l t as long-term s u r v i v o r s w i t h any a n t h r a c y c l i n e a r e not common i n the L1210 system. As expected with an N-acylated d e r i v a t i v e optimum dose l e v e l s f o r AD32 a r e at l e a s t t e n - f o l d g r e a t e r than f o r adriamycin. Before l e a v i n g t h i s group of d e r i v a t i v e s i t should be noted that t h e i r b i o l o g i c a l a c t i v i t i e s a r e g e n e r a l l y i n q u a l i t a t i v e agreement with the r e c e p t o r s i t e hypothesis d i s c u s s e d above.

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