Brain Tumors: Their Biology and Pathology by K. J. Zülch M.D. (auth.)

By K. J. Zülch M.D. (auth.)

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Bohmig reported briefly on a similar case. In our collection of cases, the brothers B. are particularly noteworthy; both of them died of glioblastomas of the parieto-occipital region. Of these, Willi B. died at the age of 54 with a right parietal glioblastoma, while George B. died of a parietal glioblastoma at the age of 61. G. Koch has furnished tables on the familial brain tumors known until 1953. He himself was able to find six instances of familial brain tumors. 1 %. Three families belonged to the group of von Recklinghausen's disease.

These are peculiar degenerative forms of fibrous cell-processes, which relate this tumor to a whole series of pathological changes occurring in the subependymal glia after inflammation, degenerative states, and even syringomyelia. There is thus considerable justification for relating spongioblastomas to a proliferation of the mature subependymal glia. Morphologically this glia occupies a position between the ependymal cell and the astrocyte and corresponds, as described by Opalski (1934), to the tumor cells of the spongioblastoma.

It corresponds principally to the large-cell astrocytoma or to the malignant form of what is ordinarily considered the large-cell astrocytoma. In my experience, the new classification of glioblastomas by Davis, Martin, Goldstein, and Askenazy into angioproliferative and angiothrombotic glioblastomas is not based on fundamental characteristics; indeed, this classification can not be adhered to in the examination of large sections, since the thromboses naturally lead to necroses, and angioproliferations arise right on the border of the cysts and necrotic areas (Zulch, 1939).

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