Atlas of Soft Tissue and Bone Pathology: With Histologic, by Leslie G. Dodd MD, Marilyn M. Bui MD PhD

By Leslie G. Dodd MD, Marilyn M. Bui MD PhD

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This is an abundantly illustrated source for prognosis of bone and delicate tissue lesionsóa specific problem because of their rarity and complexity. as well as rigorously chosen histologic pictures, this exact atlas complements general visible details with illustrations of imaging findings, cytology, and molecular and cytogenetic details. This vibrant pictorial survey is prepared in a pattern-oriented process in accordance with the particular operating approach utilized in day-by-day practice.

The authors are professional educators in surgical and cytopathology and skilled diagnosticians within the complexities of soppy tissue and bone pathology. This richly illustrated and concise reference should be a realistic and indispensible instrument for basic pathologists and pathologists in education, who're required to diagnose bone and delicate tissue pathologies. it's also a very good source for physicians looking a brief survey of sarcoma.

Key Features:

  • Offers a realistic, pattern-oriented diagnostic procedure that mirrors the operating procedure utilized in day-by-day practice
  • Augments histologic images with illustrations of imaging findings, cytology, and molecular and cytogenetic information
  • Authored by means of well-known specialist diagnosticians and academics within the field

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Extra resources for Atlas of Soft Tissue and Bone Pathology: With Histologic, Cytologic, and Radiologic Correlations

Example text

Four distinct subvariants of hibernoma have been described: typical, lipoma-like, myxoid, and spindle cell. The myxoid variant appears to be the rarest and can lead to diagnostic confusion. CYTOLOGIC FINDINGS Aspirates obtained from hibernomas tend to be cellular. Fragments of benign stroma and unremarkable fat may be identified in addition to the tumor cell population. 6). Nuclei tend to be small, round, and uniform in appearance. Lipid debris may be present in the background. 1 Hibernomas are usually lobulated and are comprised of a mixture of pale and dark staining cells.

They are a frequent finding in the spindle cell/pleomorphic variant of lipoma as well. The best method to differentiate a benign lipoma from an ALT/WDL is to use ancillary techniques. Both FISH for MDM2 amplification and immunohistochemical staining for the associated protein are available commercially. These have been successfully utilized on small specimens and are extremely helpful in separating these two look-alikes. If insufficient material is available for ancillary studies, it is perfectly acceptable to designate a tumor as a “well-differentiated lipomatous neoplasm,” with a caveat that the differential diagnosis includes both lipoma and ALT/WDL.

Although amplification of these genes is not specific for ALT/WDL, they are not amplified in other histologically similar tumors such as lipomas. 5: ATYPICAL LIPOMATOUS TUMOR/WELL-DIFFERENTIATED LIPOSARCOMA CYTOLOGIC FINDINGS Cytologically, ALT/WDL may be impossible to distinguish from a benign lipoma. These lesions tend to be composed of tight cohesive fragments of fat which cling to a fragment of fibrous tissue. The classic lipoblast is very difficult to distinguish in aspirates of ALT/WDL. 12). The nuclear atypia can be variable in appearance and may manifest as hyperchromasia or increased nuclear size and shape.

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