By Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann
content material: melanoma drug discovery and improvement : new paradigms for a brand new millennium / E.A. Sausville ... [et al.] --
Evolutionary biosynthesis of anticancer medications / George R. Pettit --
a few contemporary advancements within the synthesis and structure-activity dating of novel taxanes / John F. Kadow ... [et al.] --
New new release taxoids and hybrids of microtubule-stabilizing anticancer brokers / Iwao Ojima ... [et al.] --
Discodermolide and taxol : a synergistic drug blend in human carcinoma phone traces / Susan Band Horwitz ... [et al.] --
hugely effective semisynthesis of biologically energetic epothilone derivatives / Gregory D. Vite ... [et al.] --
artificial and semisynthetic analogs of epothilones : chemistry and organic job / Karl-Heinz Altmann ... [et al.] --
Synthesis and organic task of epothilones / Ulrich Klar ... [et al.] --
Epothilones and sarcodictyins : from combinatorial libraries to designed analogs / Nicolas Winssinger and K.C. Nicolaou --
Synthesis and structure-activity courting reviews of cryptophycins : a unique classification of effective antimitotic antitumor depsipeptides / Chuan Shih ... [et al.] --
Farnesyltransferase inhibitors as power anticancer brokers / J.B. Gibbs ... [et al.] --
Farnesyltransferase inhibitors : from squalene synthase inhibitors to the medical agent BMS-214662 / John T. Hunt --
Inhibiting farnesyl protein transferase with Sch-66336 : possibly a selective noncytotoxic treatment for human melanoma / A.G. Taveras ... [et al.] --
Pyrrolo[2,3-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives as selective inhibitors of the EGF receptor tryosine kinase / G. Caravatti ... [et al.] --
STI571 : a brand new therapy modality for CML? / Jürg Zimmermann, Pascal Furet, and Elisabeth Buchdunger --
the invention and improvement of second-generation matrix metalloproteinase inhibitors for the remedy of melanoma / Andy Baxter and John Montana --
customers for antiangiogenic remedies established upon VEGF inhibition / Pascal Furet and Paul W. Manley --
Carbohydrate-based tumor antigens as antitumor vaccine brokers / Jennifer R. Allen and Samuel J. Danishefsky --
medicines to reinforce the healing efficiency of anticancer antibodies : antibody-drug conjugates as tumor-activated prodrugs / Walter A. Blättler and Ravi V.J. Chari.
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Table 2 C-4 analogs which overcome resistance vs HCT 116(VM)46 Ο Compound? 6) 132 (3) 100(4) 183 (32) 142 (6) 144 (4) c 'Tubulin data has been previously reported (14). ^atio of I C for HCT 116(VM46)MDR resistant cell line /IC for HCT 116 sensitive cell line. Madison Murine Lung Carcinoma. Drug is given ip on days 1-5 post ip implantation. Values are %T/C analog ( maximum tolerated dose) % T/C for paclitaxel at a historically determined maximally efficacious dose. %T/C values of greater than 125 % are considered active.
1998, 120, 5597-5598. 22. Dhokte, U . ; Khau, V . ; Hutchison, D . ; Martinelli, M. J. Tetrahedron Lett. 1998, 8771-8774. 23. Nicolaou, K . C . ; Sarabia, F . ; Finlay, M. R. ; Yang, Z . J. Am. Chem. Soc. 1997, 119, 7974-7991. 24. Smith, A . ; Nicolaou, K . C . J. Med. Chem. 1996, 39, 2103-2117. 25. Schultes, R. E . ; Hoffman, A . The Botany and Chemistry of Hallucinogens; Charles C . Thomas Publisher: I L , 1973; ρ 13. 26. Bradner, W . T. In Cancer and Chemotherapy, Crooks, S. ; Prestayko, A .
Engl. 1998, 37, 192-196. Evans, D . ; Trotter, B . W . ; Coleman, P. J . ; Côté, B . ; Dias, L. ; Rajapakse, Η. ; Tyler, A . N. Tetrahedron 1999, 55, 8671-8726. Claffey, M. ; Hayes, C . J . ; Heathcock, C . H. J. Org. Chem. 1999, 64, 8267-8274. ; Guyot, M. Tetrahedron Lett. 2000, 41, 3349-3353. ; Wallace, D . J . ; Oballa, R. M. Tetrahedron Lett. 1998, 39, 8545-8548. ; Vogel, P. J. Org. Chem. 2000, 65, 3346-3356. Micalizio, G . C . ; Roush, W . R. Tetrahedron Lett. 1999, 40, 3351-3354. ; Nakata, M.