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Additional resources for Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics
He continues to work as Research Professor of Neurosciences at the University of California at San Diego. Although Dr Katzman’s initial entry into Alzheimer’s disease (AD) work was a neurochemical analysis of the ganglioside loss in the AD brain, carried out with Dr Kinuko Suzuki in 1965, and a recent ﬁnding with the late Dr Saitoh was that of an LRP polymorphism that modiﬁes the risk of AD, his major interests have been in the clinical, epidemiological and public health aspects of AD. His experience in the early 1970s as a clinician working with xxxii SCIENTISTS HONORED FOR PIONEERING RESEARCH older individuals with dementia, conﬁrmed in his mind the frequency of AD in the elderly.
Br J Psychiatry 166(5), 621–9. Fichter MM, Schroppel H, Meller I (1996) Incidence of dementia in a Munich community sample of the oldest old. Eur Arch Psychiatry Clin Neurosci 246(6), 320–8. Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B (1997) Very old women at highest risk of dementia and Alzheimer’s disease: incidence data from the Kungsholmen Project, Stockholm. Neurology 48(1), 132–8. Ganguli M, Dodge H, Chen P, Belle S, DeKosky S (2000) Ten-year incidence of dementia in a rural elderly US community population—The MoVIES Project.
4 EPIDEMIOLOGY AND RISK FACTORS TIME BEFORE DEMENTIA DIAGNOSIS Due to the insidious onset of AD, the time of diagnosis is the only deﬁnite point in the initial phase of the disease. The time of diagnosis may be deﬁned as the time when diagnostic criteria for dementia and AD are fulﬁlled. This time may be affected by several factors, including cultural, social, and medical conditions. The studies conducted so far have focused on early clinical phases, which correspond approximately to 1–2 years before or after diagnosis, and on the preclinical phase, deﬁned as occurring more than 2 years before diagnosis.