By Sudarshan K. Malhotra
A part of a chain which goals to hide contemporary wisdom within the box of neural technological know-how, this quantity discusses such subject matters as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.
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The significance of SRIF receptors on astrocytes is a matter of speculation. , 1991) that astrocytes may be involved in the removal of the peptide from the intercellular cleft or the target cell; on the other hand, glial cells may be the primary target of SRIF. , 1984) controlling the transport between ventricular and intercellular cerebrospinal fluid compartments (Kfisch and Leonhardt, 1984). , 1991). The binding sites show high affinity for SRIF (125I-Tyr0, D-TrpS-SRIF-14) and SRIF analogues (SRIF-28) and is regulated by GTP as early as day 16 of fetal age, indicating that they represent functional SRIF receptors.
These findings not only substantiate the in ovo observations but indicate that GHRH and SRIF may elicit their effects on proliferating neuroblasts (E3) and not on more mature differentiated neurons (E6). GABAergic Expression. , 1986). GABAergic neuronal elements, verified both biochemically and immunocytochemically, are present by 3 days of embryonic development in the chick embryo (Mangoura and Vernadakis, 1988). As discussed earlier, neuroblasts at this embryonic stage of development are actively proliferating and are characterized by a high degree of plasticity, as demonstrated in both cholinergic and catecholaminergic populations (Kentroti and Vernadakis, 1989, 1990a).
1978). A detailed distribution of VIP-binding sites in the rat brain has recently been described by Martin et al. (1987) using in vitro autoradiography on slide-mounted sections. High densities of binding sites are reported in olfactory bulb, cerebral cortex and dentate gyrus, subiculum, various thalamic and hypothalamic nuclei, superior colliculus, locus coeruleus, area postrema, subependymal layer, and pineal gland. Intermediate densities are found in amygdala, nucleus accumbens, caudate-putamen, septum, bed nucleus of the stria terminalis, hippocampus, and central gray.