Advances in Cancer Research, Vol. 58 by George F. Vande Woude (ed.), George Klein (ed.)

By George F. Vande Woude (ed.), George Klein (ed.)

A part of a serial which offers entire reports on advances within the wide box of melanoma learn. This quantity covers all facets of the molecular foundation of human melanoma, discussing such issues as viral interplay with lymphocytes; tumour oncogenesis, rejection and eradication.

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This leads to the possibility that exposure of cells to physiological levels of hormones or growth factors that activate the kinase C pathway may lead to an increase of TGF-a synthesis in the target cell. As mentioned above, treatment with TPA also results in an increased cleavage of the cell surface TGF-a form, thus releasing higher levels of soluble TGF-a (Pandiella and Massagut, 1991). , 1989). Thus, there is an autostimulation of TGF-a production in these cells. A molecular analysis of this phenomenon could provide us with insight not only in the regulation of TGF-a synthesis, but also in the activation of expression of other genes that are the PHYSIOLOGY OF TGF-OL 41 target of TGF-a action.

Levine, G. Pearson, and D. ), pp. 22 1-247. Nijhoff, Boston, Massachusetts. , and Sugden, B. (1981). Nature (London) 294,458-460. Klein, G. In “The Epstein-Barr Virus” (M. A. Epstein and B. G. ), pp. 339-350. Springer-Verlag, Berlin. Klein, G. (1989). Cell 58, 5-8. , and Persson, P. (1976). Znt. J. Cancer 17, 21-26. Knutson, J. , and Sugden, B. (1989). Adv. Viral Oncol. 8, 151-172. 24 ROBERT P. ROGERS E T AL. Kocache, M. , and Pearson, G. R. (1990). Intervirology 31, 1-13. Kupfer, S. , and Summers, W.

Tuffnell, P. , and Barrel], B. G. (1984). Nature (London) 310,207-21 1. Baichwal, V. , and Sugden, B. J. Virol. 61, 866-875. Bhat, R. , and Thimmappaya, B. (1985). J. Virol. 56, 750-756. , Pavlish, 0.. , Seigneurin, J. , and Lenoir, G. M. J. Virol. 63,41214128. , and Lenoir, G. M. (1990). Blood 75, 1827-1833. , and Perricaudet, M. (1986). Nucleic Acids Res. 14, 7103-7114. , and Perricaudet, M. (1986). Nucleic Acids Res. 14, 261 1-2620. , and Farrell, P. J. J. Virol. 61, 3424-3430. , and Tursz, T.

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