Advances in Cancer Research, Vol. 15 by George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

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I n all cases, it appeared that the lack of expression of certain viral genes in transformed cells was at the level of transcription. A more recent study of the regulation of SV40 gene activity in transformed cells utilized randomly labeled lytic mRNA (M. A. Martin and Axelrod, 1969). A series of SV40-transformed mouse cell lines were analyzed. The extent of transcription in the individual lines varied, ranging from 30 to 100% of that seen during lytic infection. In the latter cell line, there must be some block beyond the point of transcription which prevents the synthesis of infectious virus.

Immunofluorescence detection of SV40 S-antigen localized a t surface of cell. X 400. 26 J . S. BUTEL, S. S. TEVETHIA, AND J . L. MELNICK studies were not inbred, this probably was not a serious detriment because it has not been possible to demonstrate isoantibody in hamsters (Billingham and Silvers, 1964). Kluchareva et al. (1967) confirmed the presence of S-antigen in SV40-transformed cells, and further established the specificity of the reaction by using sera which were prepared in hamsters inoculated with live SV40 during the latent period of viral oncogenesis.

This antigen has been localized in the perinuclear region of cells infected with a strain of adenovirus type 2 carrying a defective SV40 genome (AdB'ND,). Sera from monkeys immunized with cells infected with Ad2+ND, react with an intranuclear antigen present in both SV40-transformed and SV40infected cells (Lewis and Rowe, 1971). Antibody to U-antigen is also detected in sera from SV40 tumor-bearing hamsters. I n contrast to Tantigen, U-antigen is heat-stable. The existence of U-antigen and the difficulty in obtaining specific antisera (Lewis and Rowe, 1971) reveal that future studies aimed at characterizing T-antigen will need to be carefully designed and evaluated.

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